Cerebral Therapeutics Announces Enrollment of First Patient in a Multicenter Randomized Controlled Phase 2b Trial in Epilepsy
AURORA, Colo.--(BUSINESS WIRE)--Cerebral Therapeutics, Inc., a clinical-stage pharmaceutical company developing innovative treatments for neurological diseases, today announced that the first patient has been enrolled in a Phase 2b study of intracerebroventricular drug delivery of the anti-seizure medication CT-010 in patients with medically refractory epilepsy. The trial is enrolling adult epilepsy patients with temporal lobe onset, with or without secondary generalized seizures.
A clinical feasibility study at St. Vincent’s Hospital Melbourne (published in The Lancet - EClinicalMedicine) established for the first time that intracerebroventricular administration of sodium valproate is a potentially effective strategy in the treatment of refractory epilepsy. The study found that subjects experienced a mean 77 percent seizure reduction and extended periods of seizure freedom. All subjects reported significant quality of life improvement with minimal drug side effects. Based on these promising initial results, Cerebral Therapeutics has developed a propriety formulation, CT-010, and enhanced the infusion system for continued investigation of the safety and effectiveness of the therapy.
